The Protein O-glucosyltransferase Rumi Modifies Eyes Shut to Promote Rhabdomere Separation in Drosophila
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منابع مشابه
The Protein O-glucosyltransferase Rumi Modifies Eyes Shut to Promote Rhabdomere Separation in Drosophila
The protein O-glucosyltransferase Rumi/POGLUT1 regulates Drosophila Notch signaling by adding O-glucose residues to the Notch extracellular domain. Rumi has other predicted targets including Crumbs (Crb) and Eyes shut (Eys), both of which are involved in photoreceptor development. However, whether Rumi is required for the function of Crb and Eys remains unknown. Here we report that in the absen...
متن کاملRumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase.
Mutations in rumi result in a temperature-sensitive loss of Notch signaling in Drosophila. Drosophila Rumi is a soluble, endoplasmic reticulum-retained protein with a CAP10 domain that functions as a protein O-glucosyltransferase. In human and mouse genomes, three potential Rumi homologues exist: one with a high degree of identity to Drosophila Rumi (52%), and two others with lower degrees of i...
متن کاملRegulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi.
Protein O-glucosylation is a conserved post-translational modification that occurs on epidermal growth factor-like (EGF) repeats harboring the C(1)-X-S-X-P-C(2) consensus sequence. The Drosophila protein O-glucosyltransferase (Poglut) Rumi regulates Notch signaling, but the contribution of protein O-glucosylation to mammalian Notch signaling and embryonic development is not known. Here, we show...
متن کاملEyes open, brain shut.
R E D IT R ecent progress in medical care has greatly increased the number of people who survive acute brain damage. Doctors can save the lives of many patients who suffer trauma to the brain (often after a road accident) or a lack of oxygen (for example, after a cardiac arrest or drowning), but if the damage is severe, the victim will slip into a coma. Individuals in this condition do not open...
متن کاملGetting access in PNL – eyes wide shut
Perforation of the gallbladder during percutaneous nephrolithotomy (PNL) has been described only a few times. Even if underreported, it belongs to the group of complications that happen to urologists once in their life or never, and usually at the beginning of their career. Lacerations of the liver, spleen, renal vein, inferior vena cava, and more frequent perforations of the intestines are amo...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2014
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1004795